Segway Scooter

What ever happened to the Segway Human Transporter?

Last I heard it was being tested by the US Post Office. It hasn't become a transportation sensation. Why not?
Tough to pick a best answer. Thanx to all!

Security at my alma mater college, Caltech, uses it to zoom around. Yes, I pointed and laughed. It's practical, though, because the walkways are wide and there's good visibility.

It's not a transportation sensation because it can't practically be used on existing roads, and there aren't enough wide walkways and sidewalks with good visibility! Also it's expensive.

Segway for individuals

Drug Transporters[eBook] $151.11 pA comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the bodybr / BRbr / BRThe development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:br / BRlibr / BRbr / BRProvides a comprehensive overview of drug transportersbr / BRlibr / BRbr / BRIncludes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in dru...

ABC Transporters and Multidrug Resistance $91.31 <b>A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance</b><p>ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.<p><i>ABC Transporters and Multidrug Resistance</i> offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.<p>This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.<b>PREFACE.</b><p><b>CONTRIBUTORS.</b><p><b>INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE</b> (<i>Jonathan A. Sheps and Victor Ling).</i><p><b>PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION.</b><p><b>1 The P-glycoprotein 170: Just a multidrug resi@VÓ×=p¤ÿ¾Úð

The Transporters of God $16.29 The Transporters of God

Dopamine Transporters $101.32 Dopamine Transporters

Drug Transporters $149.6 Drug Transporters

Nascar Transporters $3.3 Nascar Transporters

Transporters as Drug Carriers: Structure, Function, Substrates $149.72 This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.<br>As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. <br>For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.<br>List of Contributors.<p>Preface.<p>A Personal Foreword.<p>Part One: Human Transporter Families ? Structure, Function, Physiology.<p>1.The ABC Transporters: Structural Insights into Drug Transport (Robert C. Ford, Alhaji B. Kamis, Ian D. Kerr, and Richard Callaghan).<p>2. Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters (Marçal Pastor-Anglada, Miriam Molina-Arcas, Pedro Cano-Soldado, and Francisco Javier Casado).<p>3. Organic Anion Transporting Polypeptides (Oatps/OATPs) (Mine Yarim and Meric Koksal).<p>4. CNS-Transporters as Drug Targets (Klaus Gundertofte).<p>Part Two: Drug Transport in Microorganisms and Fungi.<p>5. Bacterial Multidrug Transporters: Molecular and Clinical Aspects (Olga Lomovskaya, Helen I. Zgurskaya, and Keith Bostian).<p>6. Membrane Transporters in Pleiotropic Drug Resistance and Stress Response in Yeast and Fungal Pathogens (Tobias Schwarzmüller, Cornelia Klein, Martin Valachovic, Walter Glaser, and Karl Kuchler).<p>Part Three: Structure Ac@b·=p£×ÿ¾Úð

Membrane Transporters in Drug Discovery and Development: Methods and P $135.95 pStudies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biologya[ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.pWide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Drug Transporters: Molecular Characterization and Role in Drug Disposi $128.56 A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body<br><br>The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:<br>*<br><br>Provides a comprehensive overview of drug transporters<br>*<br><br>Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy<br>*<br><br>Describes transporter-mediated drug disposition, a newly emerging field in drug therapy<br>*<br><br>Gives a comprehensive summary of drug transport across biological membranes<br>*<br><br>in the liver, brain, kidney, and intestine<br>*<br><br>Provides balanced coverage of mechanistic aspects and functional outcomes<br>*<br><br>Features chapters contributed by distinguished scientists in their specialty areas<br>*<br><br>Provides sufficient detail to enable non-specialists to understand the principles and techniques<br><br>This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.Contributors.<p>Preface.<p>1 Overview of Drug Transporter Families (<i>Guof@`ë…¸Rÿ¾Úð